Sugar acids and derivatives
Medchemexpress LLC BET bromodomain inhibitor 1 | 2411226-02-1 | 99.7% | 25 MG
BET bromodomain inhibitor 1 is an orally active and selective inhibitor of bromodomain and extra-terminal (BET) bromodomains. It demonstrates anti-cancer activity by inducing G1-phase cell cycle arrest, inhibiting c-Myc expression, and upregulating p21 levels. Its primary applications involve research into acute myeloid leukemia, acute leukemia, and multiple myeloma.
- Orally active and selective BET bromodomain inhibitor.
- High affinity for BRD4 (IC50: 2.6 nM) and other BET bromodomains.
- Demonstrates anti-cancer activity by inducing G1-phase cell cycle arrest.
- Effective against various cancer cell lines (Kasumi 1, MM1.S, MV4-11, and RS4-11).
- Excellent selectivity for BET bromodomain family over other bromodomains.
- Does not inhibit five cytochrome P450 enzymes.
- Exhibits strong antitumor activities in in-vivo models.
Medchemexpress LLC Lecithins, egg | 93685-90-6 | 25 MG
Lecithins, egg are pharmaceutical excipients, also known as pharmaceutical auxiliaries. These are chemical substances, other than active pharmaceutical ingredients, used in the pharmaceutical process. They are generally inactive ingredients in pharmaceutical preparations, improving stability, solubility, and processability. Additionally, they can influence the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.
- Purity: 99.0%
- Appearance: Oil
- Color: Light yellow to brown
- Solubility: Soluble in ethanol (≥ 100 mg/mL)
Medchemexpress LLC D-Thyroxine | 51-49-0 | 98.0% | C15H11I4NO4 | 25 MG
D-Thyroxine (D-T4) is an orally active thyroid hormone that inhibits the secretion of TSH. It can inhibit goiter, promote metamorphosis of tadpoles, and influence cholesterol metabolism. D-Thyroxine can be used for the study of hypercholesterolemia. This product is intended for research applications only.
- Orally active thyroid hormone
- Inhibits the secretion of TSH
- Can inhibit goiter
- Promotes metamorphosis of tadpoles
- Influences cholesterol metabolism
- Used for the study of hypercholesterolemia
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Gold Biotechnology Inc NADH Beta Reduced Sodium Salt
Reduced -nicotinamide adenine dinucleotide (NADH) plays a major role in metabolism as a cofactor in redox reactions and as a mobile electron carrier NADH is a high energy compound that donates electrons to the electron transport chain to provide energy for ATP production by oxidative phosphorylation NADH is a required oxidizing cosubstrate in fermentation which regenerates NADH is fluorescent which provides for a relatively simple way to detect NADH in biological samples NADH is also used in enzyme cycling assays to detect relevant biological molecules in tissues
Apexbio Technology LLC D-AP5(Synonyms: D-2-Amino-5-phosphonopentanoic acid, D-APV, D(-)-2-Amino-5-phosphonovaleric acid), 10mg, CAS: 79055-68-8.
D-AP5 (CAS 79055-68-8) is a selective antagonist of the NMDA receptor It competitively inhibits glutamate binding at the NMDA receptor site exhibiting an affinity constant (Kd) of approximately 1 4 M In animal research administration of D-AP5 leads to impairment in spatial learning tasks specifically causing deficits in sensorimotor function and spatial memory performance Due to its targeted action on NMDA receptors D-AP5 serves as an important pharmacological tool for studying glutamate-related synaptic plasticity learning and memory mechanisms
Medchemexpress LLC Beta-sitosterol | 83-46-5 | MFCD00003631 | 98.0% | 414.71 g·mol⁻¹ | C29H50O | 10 MG
Beta-sitosterol is a plant-derived phytosterol used as a reference standard and research reagent for studies of cell signaling, inflammation, oxidative stress, and antitumor activity. It is supplied in small quantities suitable for laboratory assays and analytical work.
- Used as a reference standard in biochemical and analytical assays.
- Relevant for studies of inflammation, oxidative stress, and cell signaling.
- High purity provides reproducible experimental results.
- Available in small package sizes suitable for bench-scale experiments.
Apexbio Technology LLC PKH26 Red Fluorescent Cell Linker Kit(Synonyms: PKH26 Cell Membrane Dye, PKH26 Fluorescent Cell Labeling Kit), 25T.
PKH26 Red Fluorescent Cell Linker Kit comprises the red fluorescent probe PKH26 designed specifically to label cellular membranes PKH26 integrates stably into lipid regions of cell membranes emitting red fluorescence and enabling clear visualization of cells Due to low cytotoxicity low nonspecific background fluorescence and minimal dye transfer to neighboring unlabeled cells PKH26 has broad utility in tracking cells both in vitro and in vivo Its fluorescence is evenly partitioned between daughter cells during proliferation diminishing with each round of cell division facilitating proliferation assays PKH26 is frequently employed alone or in combination with PKH67 for cell tracking studies and proliferation analyses
Gold Biotechnology Inc NADH Beta Reduced Sodium Salt
Reduced -nicotinamide adenine dinucleotide (NADH) plays a major role in metabolism as a cofactor in redox reactions and as a mobile electron carrier NADH is a high energy compound that donates electrons to the electron transport chain to provide energy for ATP production by oxidative phosphorylation NADH is a required oxidizing cosubstrate in fermentation which regenerates NADH is fluorescent which provides for a relatively simple way to detect NADH in biological samples NADH is also used in enzyme cycling assays to detect relevant biological molecules in tissues
Medchemexpress LLC Tetrahydrouridine dihydrate | 18771-50-1 | MFCD00063468 | 99.8% | 284.26 g/mol | C9H20N2O8 | 10 MG
Tetrahydrouridine dihydrate is the dihydrated form of tetrahydrouridine, a potent competitive inhibitor of cytidine deaminase (CDA). Supplied as a white to off-white solid for research use, it is used to inhibit cytidine deamination, support studies of DNA/RNA synthesis pathways, and sensitize carcinoma cells to cytidine analog chemotherapeutics such as gemcitabine.
- Potent competitive inhibitor of cytidine deaminase (CDA).
- High purity (≈99.8%) suitable for research applications.
- Dihydrate form; molecular weight 284.26 g/mol.
- White to off-white solid, convenient for analytical and biological assays.
- Stable when stored as powder at -20°C (long-term storage).
- Available in small assay sizes for laboratory use.