Sugar acids and derivatives
Medchemexpress LLC Complement factor D-IN-1 | 1386455-76-0 | 98.9% | 483.32 g·mol⁻1 | C21H19BrN6O3 | 10 MG
Complement factor D-IN-1 is a potent, selective, small-molecule reversible inhibitor of complement factor D intended for research into complement system biology and complement-mediated inflammation. It has been characterized in biochemical assays and is supplied as solid or solution for laboratory studies.
- Potent inhibitory activity: IC50 = 0.006 μM (FD thioesterolytic assay) and IC50 = 0.05 μM (MAC deposition assay).
- High reported purity (~98.9%); consult lot-specific COA for exact value.
- Supplied as solid or as DMSO solution for flexible experimental workflows.
- Stable storage: powder at -20°C (long term) or 4°C; in solvent, -80°C recommended.
- Molecular weight 483.32 g·mol⁻1 and formula C21H19BrN6O3 for analytical reference.
- For research use only; not for human or clinical applications.
Medchemexpress LLC Integrin alpha V beta 3 protein, mouse (biotinylated, HEK293, his-avi) | >=95.0% | 20UG
Integrin alpha V beta 3 protein is a recombinant, biotinylated heterodimer derived from mouse and expressed in HEK293 cells. It carries C-His and C-Avi tags and is glycosylated, producing an apparent molecular weight of approximately 90-130 kDa. The protein is provided for in vitro studies of integrin-mediated ligand binding, cell adhesion, signaling, and biochemical assays.
- Recombinant mouse integrin heterodimer, biotinylated and tag-labeled.
- Expressed in HEK293 cells to preserve mammalian glycosylation.
- Suitable for ligand binding assays, ELISA, SPR, and pull-down experiments.
- Useful for cell adhesion and endothelial migration studies.
- Purity ≥95% as determined by reducing SDS-PAGE.
- Provided in assay-ready small-volume format.
Medchemexpress LLC D-Glucuronic acid (standard) | 6556-12-3 | 250 MG
D-Glucuronic acid (Standard) is an analytical standard for research and analytical applications. It is a key component of anti-inflammatory proteoglycans, promoting embryonic development and inhibiting cell aggregation. Metabolized into ethyl glucuronide, it activates Toll-like receptor 4 (TLR4), potentially causing pain. This compound and its derivative glucurono-lactone act as liver detoxifiers, with derivatives also showing anti-tumor activity. It is utilized in qualitative, quantitative, and methodological research, particularly with techniques like HPLC, GC, and MS.
- Purity: 99.93%
- Molecular weight: 194.14
- Chemical formula: C6H10O7
- Appearance: Solid, white to off-white
- Promotes embryonic development
- Liver detoxifier
Medchemexpress LLC Complement factor D-IN-2 | 1903742-34-6 | 99.33% | 574.43 | 25 MG
Complement factor D-IN-2 is an inhibitor of complement factor D, extracted from patent WO2015130838A1, compound 190. It targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway, and can be used for the research of autoimmune diseases.
- Reduces the excessive activation of complement factor D.
- Targets factor D and inhibits the complement cascade.
- Suitable for research of autoimmune diseases.
- For research use only.
Sigma Aldrich Fine Chemicals Biosciences HiPrepTM Heparin Fast Flow
HiPrep(TM) Heparin FF 16/10 is prepacked with Heparin Sepharose(R) 6 Fast FLow for preparative purification of proteins with affinity for heparin such as DNA-binding proteins coagulation factors lipoproteins and protein synthesis factors.
Medchemexpress LLC OBI-992 drug-linker | 3039487-10-7 | 96.6% | 2173.46 | 1 MG
OBI-992 drug-linker is a drug-linker conjugate composed of a TOP I inhibitor Exatecan (HY-13631) and a linker. It exhibits antitumor property in mouse models and can be used for the synthesis of ADC OBI-992.
- Composed of a TOP I inhibitor and a linker
- Exhibits antitumor properties in mouse models
- Can be used for the synthesis of ADC OBI-992
Medchemexpress LLC AMG 333 | 1416799-28-4 | 99.8% | 453.32 | 25 MG
AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC50 of 13 nM. It dose-dependently inhibits wet-dog shake behavior and blocks blood pressure elevation in rat models, making it a clinical candidate for the treatment of migraine.
- Orally active and highly selective TRPM8 antagonist
- Dose-dependently inhibits wet-dog shake behavior in the Icilin-induced wet-dog shake Sprague-Dawley rat model
- Dose-dependently blocks blood pressure elevation in the cold stimulation-induced blood pressure elevation Sprague-Dawley rat model
- A clinical candidate for the treatment of migraine
Medchemexpress LLC Platycodin D | 58479-68-8 | 1225.32 | 25 MG
Platycodin D is a saponin isolated from *Platycodon grandiflorus*. It acts as an activator of AMPKα and possesses anti-obesity properties. The WNT/β-catenin pathway mediates its anti-adipogenic effect.
- Saponin isolated from *Platycodon grandiflorus*.
- Activator of AMPKα.
- Anti-obesity property.
- WNT/β-catenin pathway mediates its anti-adipogenic effect.
Medchemexpress LLC Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)- | 838810-96-1 | 98.0% | 25 MG
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). It demonstrates strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) and functions as an antivirulence agent, effectively reversing β-lactam resistance in Methicillin-resistant strains (MRSA).
- Potent synergism with cefuroxime
- Reduces β-lactam MIC against S. aureus USA300
- Enhances activity against S. aureus clinical isolates
- Potentiates effects against various circulating MRSA strains
- Synergizes with antimicrobial peptides colistin and polymyxin B
- Inhibits mprF expression
- Inhibits citrate-induced biofilm formation
- Effective as monotherapy for MRSA-infected larvae
- Increases survival in drug-treated larvae
- Correlates with concentration-dependent bacterial killing
Medchemexpress LLC D-KLVFFA | 342877-55-8 | 99.3% | 723.90 | 10 MG
D-KLVFFA is an inhibitor of Amyloid-β assembly, with an IC50 of 2.6 μM. It can be utilized in Alzheimer's disease studies, offering insights into amyloid-beta aggregation pathways.
- Inhibits amyloid-β assembly
- Useful in Alzheimer's disease studies
- Molecular weight of 723.90
- Purity of 99.3%
Medchemexpress LLC Rose-β-D-gal | 138182-21-5 | MFCD00467206 | 99.7% | 329.73 g/mol | C14H16ClNO6 | 25 MG
Rose-β-D-Gal is a chromogenic β-galactosidase substrate that produces a pink/magenta color upon enzymatic cleavage. It is used to detect β-gal activity in biochemical and cell-based assays where a visible color change is required.
- Produces a pink/magenta chromogenic signal for β-gal activity detection.
- Suitable for enzymatic assays and staining applications.
- High reported purity (99.71%) for consistent performance.
- Solid reagent supplied in small milligram quantities for research use.
- Compatible with colorimetric readouts and microscopy.
Medchemexpress LLC Ethyl glucuronide | 17685-04-0 | 99.2% | 222.19 | 1 ML
Ethyl glucuronide is an endogenous metabolite of ethanol. It serves as a biomarker for ethanol exposure, accumulating in hair and reflecting alcohol intake over time. It is also an agonist for TLR4.
- Endogenous metabolite
- Biomarker for ethanol exposure
- Agonist for TLR4
- Appearance: Solid, white to off-white
- Storage: -20°C, protect from light, stored under nitrogen. In solvent: -80°C for 6 months; -20°C for 1 month (protect from light, stored under nitrogen).
- Useful in research for studying ethanol exposure and its effects
- Can be used to block the formation of the TLR4-MD2 complex and stimulate the expression of TLR4-dependent SEAP protein in HEK-TLR4 cells
- Has been shown to reduce tactile threshold and induce hyperalgesia in Sprague-Dawley rat models
Medchemexpress LLC Integrin alpha V bet 100ug | 100ug
Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein expressed by HEK293 with C-His C-Avi labeled tag Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) has molecular weight of 90-150 kDa
Medchemexpress LLC Integrin alpha V beta 3 protein, mouse (HEK293, His) | >95.0% | 50UG
Integrin alpha V beta 3 protein, mouse (HEK293, His) is a recombinant heterodimeric integrin complex produced in HEK293 cells and supplied with a C-terminal His tag. It is intended for research use to support studies of integrin-mediated cell adhesion, signaling, and ligand interactions.
- Recombinant heterodimeric integrin complex (ITGAV:ITGB3).
- Expressed in HEK293 mammalian cells.
- C-terminal His tag for detection and purification.
- Purity greater than 95% as determined by reducing Tris-Bis PAGE.
- Observed molecular weight 90-130 kDa.
- Available in small-scale sizes suitable for biochemical assays (20 μg, 50 μg, 100 μg).
- For research use only; not for therapeutic or diagnostic use.